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FLASH GENE
Symbol FAR1 contributors: mct - updated : 04-12-2014
HGNC name fatty acyl CoA reductase 1
HGNC id 26222
Corresponding disease
RCDP4 rhizomelic chondrodysplasia punctata, type 4
Location 11p15.2      Physical location : 13.690.205 - 13.753.891
Synonym name
  • male sterility domain containing 2
  • short chain dehydrogenase/reductase family 10E, member 1
  • putative fatty acyl reductase
  • Synonym symbol(s) MLSTD2, FLJ22728, SDR10E1, DKFZp686A0370, DKFZp686P18247, FLJ33561
    EC.number 1.2.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 63.69 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 5292 59.23 515 - 2008 19027726
    EXPRESSION
    Rna function brain
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Nervousbrainhindbraincerebellum  
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • hydrophobic C terminus binding to PEX19
  • HOMOLOGY
    Homologene
    FAMILY
  • fatty acyl-CoA reductase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • dehydrogenase/reductase activity
  • reduced fatty acids to fatty alcohols
  • involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics
  • FAR1 activity is elevated in plasmalogen-deficient cells, and conversely, the levels of this enzyme are restored to normal upon plasmalogen supplementation
  • essential for supplying fatty alcohols required for ether bond formation in ether glycerophospholipid synthesis
  • peroxisomal tail-anchored protein
  • is a rate-limiting enzyme for plasmalogen synthesis
  • reduces fatty acids to their respective fatty alcohols for the plasmalogen-biosynthesis pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • NADPH
  • protein
    cell & other
  • preferred saturated and unsaturated fatty acids of 16 or 18 carbons as substrates
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RCDP4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS