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FLASH GENE
Symbol MICALCL contributors: mct/npt - updated : 29/11/2008
HGNC name MICAL C-terminal like
HGNC id 25933
Location 11p15.3      Physical location : 12.308.446 - 12.380.691
Synonym name
  • extracellular signal-regulated kinase (ERK) 2-binding protein
  • Ebitein 1
    • Synonym symbol(s) Ebitein1, FLJ14966
    DNA
    TYPE functioning gene
    STRUCTURE 72.24 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3044 77 695 - Terman (2002)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Reproductivemale systemtestis  highly Homo sapiens
    Respiratoryrespiratory tractlarynx   
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • MAPK1-binding domain required for phosphorylation of MICALCL
    • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • MICAL family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • having a function in plexin-mediated axonal repulsion
  • interactor of MAPK1 in the intracellular signal transduction pathway that occurs during the morphogenetic
  • downstream interactor of MAPK1 that participates in the intracellular signal transduction pathway mediating the morphogenetic development of round spermatids into spermatozoa development of round spermatids to spermatozoa
  • downstream interactor of MAPK1 that participates in the intracellular signal transduction pathway mediating the morphogenetic development of round spermatids into spermatozoa
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to nonphosphorylated and phosphorylated forms of MAPK3 and MAPK1 (MAPK1-binding domain was required for phosphorylation of EBITEIN1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS