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FLASH GENE

Symbol

ST8SIA6

contributors: mlc - updated : 27-10-2007

HGNC name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
HGNC id	23317

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10p12.33      Physical location : 17.362.676 - 17.496.254
Synonym name	sialyltransferase 8F (alpha-2, 8-sialyltransferase)
	alpha-2,8-sialyltransferase
Synonym symbol(s)	SIAT8F, ST8SIA-VI, ST8Sia VI
EC.number	2.4.99.8

DNA

TYPE	functioning gene
STRUCTURE	134.00 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 8 - 1398 - 398 - Avril (2006)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Reproductive female system breast mammary gland       female system ovary         male system testis       Skin/Tegument skin         Urinary bladder           kidney       predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conserved motifs of sialyltransferases

HOMOLOGY

Homologene

FAMILY

glycosyltransferase 29 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	prefers O-glycans to N-glycans or glycolipids as acceptor substrates
	exhibited activity toward oligosaccharides such as sialyllactose and sialyllactosamine

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

protein

signaling

protein glycosylation

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS