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FLASH GENE

Symbol

NARF

contributors: mct - updated : 21-05-2008

HGNC name	nuclear prelamin A recognition factor
HGNC id	29916

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q25.3      Physical location : 80.416.059 - 80.446.141
Synonym name	LET1 like/JFP15
	protein related to Narf
	prenyl-dependent prelamin A binding protein
Synonym symbol(s)	FLJ10067, IOP2

DNA

TYPE	functioning gene
STRUCTURE	29.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 12 polyA site 1638 variant 1 - 456 - Barton (1999), Lattanzi (2007) 2 potential nuclear localization signals variant 2 - polyA site 1776 variant 2 56.2 502 - Barton (1999), Lattanzi (2007) biological validity not determined experimemtally variant 3 - - 1796 - 397 - Lattanzi (2007) variant 4 - - 1494 - 408 - Lattanzi (2007)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     lowly   liver       lowly Nervous brain       highly Reproductive female system uterus cervix   lowly   male system testis     moderately Respiratory lung       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal

cell lineage
cell lines	moderate to poorly differentiated invasive carcinoma
	liposarcoma
	follicular carcinoma
	endometrioid ovarian metastasis
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nuclear envelope,lamina
text	colocalized with LMNA at the nuclear lamina

basic FUNCTION	nemo-like kinase (NLK)-associated ring finger protein that regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor
	involved in electron transport
	having ferredoxin hydrogenase activity
	involved in heterochromatin organization

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

signaling

a component

component of a prelamin A endoprotease complex

INTERACTION

DNA

RNA

small molecule

protein

specifically binding to the farnesylated prelamin A C-terminal domain (preAct)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS