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Symbol TRMT5 contributors: mct - updated : 18-09-2015
HGNC name TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)
HGNC id 23141
Corresponding disease
COXPD26 combined oxidative phosphorylation deficiency-26
Location 14q23.1      Physical location : 61.438.168 - 61.447.782
Synonym name
  • TRM5 tRNA methyltransferase 5 homolog
  • TRMT5 protein
    • Synonym symbol(s) KIAA1393, MGC111453, TRM5
    EC.number 2.1.1.228
    DNA
    TYPE functioning gene
    STRUCTURE 9.73 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 5304 - 509 - 2004 1524878
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		tRNA modification enzyme domain
    HOMOLOGY
    interspecies ortholog to chimpanzee Trmt5
    ortholog to dog loc480347
    Homologene
    FAMILY HMGN family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text
  • is localized within mitochondria in human cells
    • basic FUNCTION
  • may be involved in methionine biosynthese, transport and/or utilisation
  • mitochondrial protein with strong homology to members of the class I-like methyltransferase superfamily
  • is the methyltransferase responsible for m1G37 modification in human mitochondrial tRNAs
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COXPD26
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS