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FLASH GENE
Symbol TRMT5 contributors: mct - updated : 18-09-2015
HGNC name TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)
HGNC id 23141
DNA
TYPE functioning gene
STRUCTURE 9.73 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5304 - 509 - 2004 1524878
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
tRNA modification enzyme domain
HOMOLOGY
interspecies ortholog to chimpanzee Trmt5
ortholog to dog loc480347
Homologene
FAMILY HMGN family
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,nucleus
text
  • is localized within mitochondria in human cells
  • basic FUNCTION
  • may be involved in methionine biosynthese, transport and/or utilisation
  • mitochondrial protein with strong homology to members of the class I-like methyltransferase superfamily
  • is the methyltransferase responsible for m1G37 modification in human mitochondrial tRNAs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COXPD26
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS