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FLASH GENE
Symbol UTP14A contributors: npt/mct - updated : 17-09-2019
HGNC name UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
HGNC id 10665
Location Xq25      Physical location : 129.040.096 - 129.063.737
Synonym name
  • serologically defined colon cancer antigen 16
  • U3 small nucleolar RNA-associated protein 14 homolog A
  • antigen NY-CO-16
    • Synonym symbol(s) NY-CO-16, SDCCAG16, KIAA0266, dJ537K23.3
    DNA
    TYPE functioning gene
    STRUCTURE 23.57 kb     15 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2509 87 771 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestine   
    Lymphoid/Immunetonsils   predominantly
    cell lineage
    cell lines various cancer
    fluid/secretion serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • UTP14 family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • playing a role in normal spermatogenic cell development
  • UTP14A is a direct interaction partner of DHX37 and can likely act as a cofactor that stimulates the activity of the helicase in the context of U3 snoRNA release
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • conserved sequence motif in UTP14A interacts with and activates DHX37 by stimulating its ATPase activity and enhancing RNA binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS