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FLASH GENE
Symbol RAD21L1 contributors: mct - updated : 29-09-2016
HGNC name RAD21-like 1 (S. pombe)
HGNC id 16271
Location 20p13      Physical location : 1.206.763 - 1.235.145
Synonym name double-strand-break repair protein rad21-like protein 1
Synonym symbol(s) dJ545L17.2, MGC198626, RAD21L
DNA
TYPE functioning gene
STRUCTURE 29.82 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1808 - 556 - 2001 PMID: 117800
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • rad21 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • replaces RAD21 in premeiotic S phase, becomes detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene
  • localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21
    • basic FUNCTION
  • implicated in DNA repair
  • cohesin complexes containing RAD21L1 may be involved in synapsis initiation and crossover recombination between homologous chromosomes
  • cohesin complex (CC), meiotic-specific, constituted by this alpha-kleisin and expand the view of REC8 as the only specific meiotic alpha-kleisin
  • essential for male fertility and in females for the maintenance of fertility during natural aging
  • RAD21L1 and REC8 were not symmetrical in terms of synaptic homologs, suggesting that the arrangement of different cohesins is not strictly fixed along all chromosome axes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with other cohesin subunits such as SMC1A, SMC1Bb, SMC3 and with the meiosis-specific STAG3 protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • male mice lacking Rad21l are defective in full synapsis of homologous chromosomes at meiotic prophase I, which provokes an arrest at zygotene and leads to total azoospermia and consequently infertility, however Rad21l-deficient females are fertile but develop an age-dependent sterility