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FLASH GENE
Symbol DDX50 contributors: npt/ - updated : 12-05-2006
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
HGNC id 17906
Location 10q21.3      Physical location : 70.661.033 - 70.706.602
Synonym name
  • GU2 nucleolar protein
  • RNA helicase II/Gu beta
  • DEAD/H (Asp-Glu-Alz-Asp/His) box polypeptide 21L
    • Synonym symbol(s) DDX21L, GUB, MGC3199, RH-II/GuB, GU2, Gu-beta
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text arranged in tandem with DDX21
    STRUCTURE 45.57 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure no TATA box
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text several trancripts resulting from exon inclusion or exon skipping
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2575 82.4 737 - Valdez (2002)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal DEAD/H box (Asp-Glu-Ala-Asp/His)
  • dsRNA helicase domain
  • a ssRNA foldase C terminal domain
    • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX21/DDX50 subfamily
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • unwinding double stranded RNA and folding single stranded RNA
    • CELLULAR PROCESS protein, editing
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text ribosomal RNA biogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS