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FLASH GENE
Symbol UGT1A9 contributors: mct/npt - updated : 24-04-2009
HGNC name UDP glycosyltransferase 1 family, polypeptide A9
HGNC id 12541
Location 2q37.1      Physical location : 234.580.543 - 234.681.949
Synonym name UDP-glucuronosyltransferase 1A9
Synonym symbol(s) HLUGP4, LUGP4, UGT1AI, GNT1, UDPGT, UGT-1I, UGT1, UGT1.9,
EC.number 2.4.1.17
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text see UGT1A@
STRUCTURE 101.41 kb     6 Exon(s)
regulatory sequence Promoter
Binding site   HRE
text structure
  • specific promoter/first exon spliced to common exons 2 to 5
  • Xenobiotic (XRE) and antioxidant (ARE) response elements were detected in the promoters of UGT1A8, UGT1A9, and UGT1A10 (Kalthoff 2010)
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2395 57.3 530 - Bosma (1992)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver    
    Gustatory (taste)tongue    
    Urinarybladder   highly
     kidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Ugt1a8
    intraspecies homolog to UGT1A10 (93 p100)
    Homologene
    FAMILY
  • UDP-glycosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • transfer of glucuronic acid (or other nucleotide sugars) to bilirubin
  • catalyze the transfer of glucuronic acid from UDP-glucuronic acid to endo- and xenobiotics in our body (Patana 2008)
  • having a major role in the elimination of lipophilic chemicals by glucuronidation
  • catalyze the glucuronidation of xenobiotics, mutagens, and reactive metabolites and thus act as indirect antioxidants (Kalthoff 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to colon cancer (Girard (2008)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS