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FLASH GENE

Symbol

MS4A2

contributors: mct - updated : 11-02-2015

HGNC name	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
HGNC id	7316

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Homo sapiens   spleen         Homo sapiens   thymus         Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell not specific mast cell Homo sapiens

cell lineage
cell lines	erythroleukemia cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a short intracellular domain
	four transmembrane segments (4TM)
	a long cytoplasmic tail, involved in intracellular signaling

HOMOLOGY

intraspecies

homolog to B cell specific receptor CD20

Homologene

FAMILY

membrane-spanning 4-domains (MS4A) family

CATEGORY

signaling , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endosome
text	mainly localized in the cell membrane of mast cells

basic FUNCTION	involved in the regulation of B cell activation and proliferation
	acts as a critical element in mast cell synergistic degranulation response through FCER1A
	cytoplasmic MS4A2, which is not co-localized with FCER1A, may function as a negative regulator, as it can capture important signalling molecules such as LYN

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

component of oligomeric cell surface complex involved in signal transduction

INTERACTION

DNA

RNA

small molecule

protein	is a key regulator of IgE expression and function, and IgE signaling suppresses MS4A2 expression
	HDAC3 mediates allergic skin inflammation in relation with angiogenesis by regulating MS4A2
	HDAC3 exerted a negative regulation on expression of HDAC2 via interaction with RAC1
	HDAC2, negatively regulated by MS4A2 and HDAC3, is under the control of proteasome-dependent ubiquitination
	interaction between LYN and MS4A2 is indispensable for FCER1-mediated human mast cells activation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed allergy     specific inhibition of the interaction with LYN may represent a new therapeutic strategy for the treatment of human allergic diseases

ANIMAL & CELL MODELS