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FLASH GENE

Symbol

MS4A2

contributors: - updated : 24-02-2004

HGNC name	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
HGNC id	7316

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Lymphoid/Immune lymph node

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell

cell lineage
cell lines	erythroleukemia cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a short intracellular domain
	four transmembrane segments (4TM)
	a long cytoplasmic tail, involved in intracellular signaling

HOMOLOGY

intraspecies

homolog to B cell specific receptor CD20

Homologene

FAMILY

membrane-spanning 4-domains (MS4A) family

CATEGORY

signaling , receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

involved in the regulation of B cell activation and proliferation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

component of oligomeric cell surface complex involved in signal transduction

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS