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FLASH GENE
Symbol MS4A2 contributors: mct - updated : 11-02-2015
HGNC name membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
HGNC id 7316
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 10.21 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • GATA2 transactivates the MS4A2 promoter via direct binding
  • MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC390193 11 similar to olfactory receptor MOR215-1 LOC390194 11 similar to olfactory receptor MOR215-1 LOC390195 11 similar to Olfactory receptor 5AN1 LOC390196 11 similar to seven transmembrane helix receptor LOC219981 11q12.2 similar to Olfactory receptor 5A2 LOC219982 11q12.2 similar to Olfactory receptor 5A1 (OST181) LOC219983 11q12.2 similar to Olfactory receptor 4D6 LOC390197 11 similar to seven transmembrane helix receptor LOC390198 11 similar to seven transmembrane helix receptor LOC219986 11q12.2 similar to seven transmembrane helix receptor LOC390199 11 similar to Olfactory receptor 4D9 LOC390200 11 similar to olfactory receptor MOR239-1 OSBP 11q12.2 oxysterol binding protein FLJ36874 11q12.2 hypothetical protein FLJ36874 LOC390201 11 similar to seven transmembrane helix receptor LOC390202 11 similar to olfactory receptor GA_x6K02T2RE5P-2207258-2206302 STX3A 11q12.1 syntaxin 3A MRPL16 11q12-q13.1 mitochondrial ribosomal protein L16 GIF 11q12.2 gastric intrinsic factor (vitamin B synthesis) TCN1 11q11-q12 transcobalamin I (vitamin B12 binding protein, R binder family) LOC390203 11 similar to hypothetical protein FLJ13352 LOC255649 11q12.2 hypothetical LOC255649 FLJ36198 11q12.2 hypothetical protein FLJ36198 MS4A3 11q12 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) MS4A2 11q12.2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) MS4A6A 11q12.1 membrane-spanning 4-domains, subfamily A, member 6A LOC390204 11 similar to membrane-spanning 4-domains, subfamily A, member 4 isoform b; membrane-spanning 4-domains, subfamily A, member 4A; four-span transmembrane protein; Fc epsilon receptor beta subunit homolog MS4A4A 11q12 membrane-spanning 4-domains, subfamily A, member 4 MS4A6E 11q12.1 membrane-spanning 4-domains, subfamily A, member 6E MS4A7 11q12.1 membrane-spanning 4-domains, subfamily A, member 7 NYD-SP21 11q12.2 testes development-related NYD-SP21 MS4A5 11q12 membrane-spanning 4-domains, subfamily A, member 5 MS4A1 11q12.2-q13.1 membrane-spanning 4-domains, subfamily A, member 1 MS4A12 11q12.1 membrane-spanning 4-domains, subfamily A, member 12 MGC39681 11q12.2 hypothetical protein MGC39681 MS4A8B 11q12.1 membrane-spanning 4-domains, subfamily A, member 8B MGC35295 11q12.2 hypothetical protein MGC35295 LOC341116 11q12.2 similar to Membrane-spanning 4-domains subfamily A member 10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3658 - 244 - 2001 11245982
    6 - 3529 - 199 - 2001 11245982
    - - - - - - 2013 23643722
  • contains a putative calmodulin-binding domain
  • is critical for microtubule formation and degranulation and it may perform this function by trafficking adaptor molecules and kinases to the pericentrosomal and Golgi region in response to Ca2+ signals
  • calmodulin binding to t-FCER1B in the presence of Ca2+ could be critical for its function
  • represents a therapeutic target for the downregulation of allergic inflammation
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    Homo sapiens
     spleen    Homo sapiens
     thymus    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    not specificmast cell Homo sapiens
    cell lineage
    cell lines erythroleukemia cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short intracellular domain
  • four transmembrane segments (4TM)
  • a long cytoplasmic tail, involved in intracellular signaling
  • HOMOLOGY
    intraspecies homolog to B cell specific receptor CD20
    Homologene
    FAMILY membrane-spanning 4-domains (MS4A) family
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    text
  • mainly localized in the cell membrane of mast cells
  • basic FUNCTION
  • involved in the regulation of B cell activation and proliferation
  • acts as a critical element in mast cell synergistic degranulation response through FCER1A
  • cytoplasmic MS4A2, which is not co-localized with FCER1A, may function as a negative regulator, as it can capture important signalling molecules such as LYN
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of oligomeric cell surface complex involved in signal transduction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a key regulator of IgE expression and function, and IgE signaling suppresses MS4A2 expression
  • HDAC3 mediates allergic skin inflammation in relation with angiogenesis by regulating MS4A2
  • HDAC3 exerted a negative regulation on expression of HDAC2 via interaction with RAC1
  • HDAC2, negatively regulated by MS4A2 and HDAC3, is under the control of proteasome-dependent ubiquitination
  • interaction between LYN and MS4A2 is indispensable for FCER1-mediated human mast cells activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergy  
    specific inhibition of the interaction with LYN may represent a new therapeutic strategy for the treatment of human allergic diseases
    ANIMAL & CELL MODELS