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FLASH GENE

Symbol

MS4A2

contributors: mct - updated : 11-02-2015

HGNC name	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
HGNC id	7316

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	10.21 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	GATA2 transactivates the MS4A2 promoter via direct binding

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000139 7 - 3658 NP_000130 - 244 - 2001 11245982 NM_001256916 6 - 3529 NP_001243845 - 199 - 2001 11245982 t-FCER1B - - - - - - 2013 23643722 contains a putative calmodulin-binding domain is critical for microtubule formation and degranulation and it may perform this function by trafficking adaptor molecules and kinases to the pericentrosomal and Golgi region in response to Ca2+ signals calmodulin binding to t-FCER1B in the presence of Ca2+ could be critical for its function represents a therapeutic target for the downregulation of allergic inflammation

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Homo sapiens   spleen         Homo sapiens   thymus         Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell not specific mast cell Homo sapiens

cell lineage
cell lines	erythroleukemia cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a short intracellular domain
	four transmembrane segments (4TM)
	a long cytoplasmic tail, involved in intracellular signaling

HOMOLOGY

intraspecies

homolog to B cell specific receptor CD20

Homologene

FAMILY

membrane-spanning 4-domains (MS4A) family

CATEGORY

signaling , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endosome
text	mainly localized in the cell membrane of mast cells

basic FUNCTION	involved in the regulation of B cell activation and proliferation
	acts as a critical element in mast cell synergistic degranulation response through FCER1A
	cytoplasmic MS4A2, which is not co-localized with FCER1A, may function as a negative regulator, as it can capture important signalling molecules such as LYN

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

component of oligomeric cell surface complex involved in signal transduction

INTERACTION

DNA

RNA

small molecule

protein	is a key regulator of IgE expression and function, and IgE signaling suppresses MS4A2 expression
	HDAC3 mediates allergic skin inflammation in relation with angiogenesis by regulating MS4A2
	HDAC3 exerted a negative regulation on expression of HDAC2 via interaction with RAC1
	HDAC2, negatively regulated by MS4A2 and HDAC3, is under the control of proteasome-dependent ubiquitination
	interaction between LYN and MS4A2 is indispensable for FCER1-mediated human mast cells activation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed allergy     specific inhibition of the interaction with LYN may represent a new therapeutic strategy for the treatment of human allergic diseases

ANIMAL & CELL MODELS