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FLASH GENE
Symbol MS4A2 contributors: mct - updated : 11-02-2015
HGNC name membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
HGNC id 7316
Location 11q12.1      Physical location : 59.856.136 - 59.865.939
Synonym name
  • cell differentiation antigen CD20 (gp35), 37/35kDa, identified by monoclonal antibodies B1, 1F5
  • IgE responsiveness (atopic)
  • IgE Fc receptor subunit beta
  • immunoglobulin E receptor, high affinity, beta polypeptide
    • Synonym symbol(s) FCER1B, IGER, APY, MS4A1, ATOPY, FCERI, IGEL, IGHER
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 10.21 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • GATA2 transactivates the MS4A2 promoter via direct binding
    • MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3658 - 244 - 2001 11245982
    6 - 3529 - 199 - 2001 11245982
    - - - - - - 2013 23643722
  • contains a putative calmodulin-binding domain
  • is critical for microtubule formation and degranulation and it may perform this function by trafficking adaptor molecules and kinases to the pericentrosomal and Golgi region in response to Ca2+ signals
  • calmodulin binding to t-FCER1B in the presence of Ca2+ could be critical for its function
  • represents a therapeutic target for the downregulation of allergic inflammation
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    Homo sapiens
     spleen    Homo sapiens
     thymus    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    not specificmast cell Homo sapiens
    cell lineage
    cell lines erythroleukemia cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short intracellular domain
  • four transmembrane segments (4TM)
  • a long cytoplasmic tail, involved in intracellular signaling
    • HOMOLOGY
    intraspecies homolog to B cell specific receptor CD20
    Homologene
    FAMILY membrane-spanning 4-domains (MS4A) family
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    text
  • mainly localized in the cell membrane of mast cells
    • basic FUNCTION
  • involved in the regulation of B cell activation and proliferation
  • acts as a critical element in mast cell synergistic degranulation response through FCER1A
  • cytoplasmic MS4A2, which is not co-localized with FCER1A, may function as a negative regulator, as it can capture important signalling molecules such as LYN
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of oligomeric cell surface complex involved in signal transduction
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a key regulator of IgE expression and function, and IgE signaling suppresses MS4A2 expression
  • HDAC3 mediates allergic skin inflammation in relation with angiogenesis by regulating MS4A2
  • HDAC3 exerted a negative regulation on expression of HDAC2 via interaction with RAC1
  • HDAC2, negatively regulated by MS4A2 and HDAC3, is under the control of proteasome-dependent ubiquitination
  • interaction between LYN and MS4A2 is indispensable for FCER1-mediated human mast cells activation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergy  
    specific inhibition of the interaction with LYN may represent a new therapeutic strategy for the treatment of human allergic diseases
    ANIMAL & CELL MODELS