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FLASH GENE

Symbol

KLK11

contributors: mct - updated : 16-04-2020

HGNC name	kallikrein-related peptidase 11
HGNC id	6359

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in advanced and more aggressive prostate tumors, with up-regulation of TMPRSS2 gene in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness tumoral     --other   expressed in ER(+) breast cancer cells may play a crucial role in breast cancer progression by increasing the bioavailability of IGFs via degradation of IGFBP3 tumoral     --over   increased KLK10 and KLK11 protein expression is associated with favorable prognosis in advanced high-grade serous ovarian cancer tumoral       gain of function in colorectal tumors

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	KLK11 mRNA expression is a novel and independent biomarker in laryngeal cancer for diagnostic and prognostic purposes
	KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma
	potential independent prognostic marker for gastric carcinoma
	high KLK11 but not the other KLK mRNA levels can be considered as strong independent favorable prognostic factor in this major ovarian cancer subtype
	potential biomarker for poor prognosis in patients with esophageal squamous cell carcinoma (ESCC)
Therapy target

ANIMAL & CELL MODELS