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FLASH GENE
Symbol KLK11 contributors: mct - updated : 16-04-2020
HGNC name kallikrein-related peptidase 11
HGNC id 6359
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic region
  • one signal peptide
  • three key aminoacids essential for serine protease activity
    • HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • kallikrein-related family of proteases
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • multifunctinal protease cleaving several substrates for kallikrein and trypsin
  • involved in normal physiology processes in bronchus
  • estrogen-sensitive kallikreins with KLK14, and KLK10, all synergistically enhanced and upregulated by androgens in breast cancer cells via a membrane bound androgen receptor
  • KLK3, KLK4, KLK11, and KLK2, belong to the prostatic group of the KLKs, whose major physiological function is semen liquefaction during the fertilization process
  • KLK11 played a key role in inhibiting esophageal squamous cell carcinoma (ESCC) carcinogenesis and progression
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of KLK proteolytic cascade with KLK1 and KLK3, activated by KLK14
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in advanced and more aggressive prostate tumors, with up-regulation of TMPRSS2 gene in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness
    tumoral     --other  
    expressed in ER(+) breast cancer cells may play a crucial role in breast cancer progression by increasing the bioavailability of IGFs via degradation of IGFBP3
    tumoral     --over  
    increased KLK10 and KLK11 protein expression is associated with favorable prognosis in advanced high-grade serous ovarian cancer
    tumoral       gain of function
    in colorectal tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KLK11 mRNA expression is a novel and independent biomarker in laryngeal cancer for diagnostic and prognostic purposes
  • KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma
  • potential independent prognostic marker for gastric carcinoma
  • high KLK11 but not the other KLK mRNA levels can be considered as strong independent favorable prognostic factor in this major ovarian cancer subtype
  • potential biomarker for poor prognosis in patients with esophageal squamous cell carcinoma (ESCC)
    • Therapy target
    ANIMAL & CELL MODELS