Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

KLK11

contributors: mct - updated : 16-04-2020

HGNC name	kallikrein-related peptidase 11
HGNC id	6359

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.41      Physical location : 51.525.486 - 51.531.290
Synonym name	hippostasin
	serine protease 20
	protease, serine, 20 trypsin-like
	protease, serine, trypsin-like
	kallikrein 11
Synonym symbol(s)	TLSP, PRSS20, KLKB, MGC33060
EC.number	3.4.21-

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	tightly clustered multigene family on chromosome 19q13.4
STRUCTURE	5.80 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	not only alternative splicing but also tissue-specific use of multiple promoters regulate the expression and intracellular trafficking of KLK11/hippostasin isoforms

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - KLK3 - KLK2 - KLK4 - KLK5 - KLK6 - KLK7 - KLK8 - KLK9 - KLK10 - KLK11 - qter

regionally located

clustered with kallikrein gene family

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006853 6 splicing 1207 NP_006844 - 250 brain (hippocampus) 1998 9765601 NM_144947 6 splicing 1289 NP_659196 - 282 prostate 1998 9765601 NM_001136032 6 - 1195 NP_001129504 - 250 - 1998 9765601 NM_001167605 6 - 1282 NP_001161077 - 275 - 1998 9765601

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Nervous brain diencephalon hypothalamus   highly   brain hindbrain cerebellum     Reproductive female system breast     highly Homo sapiens   male system prostate     highly Urinary kidney tubule     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Epithelial secretory glandular

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage
cell lines	prostate cancer cell lines (only variant 1)
fluid/secretion	sperm

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal hydrophobic region
	one signal peptide
	three key aminoacids essential for serine protease activity

HOMOLOGY

Homologene

FAMILY	peptidase S1 family
	kallikrein-related family of proteases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic,granule

basic FUNCTION	multifunctinal protease cleaving several substrates for kallikrein and trypsin
	involved in normal physiology processes in bronchus
	estrogen-sensitive kallikreins with KLK14, and KLK10, all synergistically enhanced and upregulated by androgens in breast cancer cells via a membrane bound androgen receptor
	KLK3, KLK4, KLK11, and KLK2, belong to the prostatic group of the KLKs, whose major physiological function is semen liquefaction during the fertilization process
	KLK11 played a key role in inhibiting esophageal squamous cell carcinoma (ESCC) carcinogenesis and progression

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of KLK proteolytic cascade with KLK1 and KLK3, activated by KLK14

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in advanced and more aggressive prostate tumors, with up-regulation of TMPRSS2 gene in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness tumoral     --other   expressed in ER(+) breast cancer cells may play a crucial role in breast cancer progression by increasing the bioavailability of IGFs via degradation of IGFBP3 tumoral     --over   increased KLK10 and KLK11 protein expression is associated with favorable prognosis in advanced high-grade serous ovarian cancer tumoral       gain of function in colorectal tumors

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	KLK11 mRNA expression is a novel and independent biomarker in laryngeal cancer for diagnostic and prognostic purposes
	KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma
	potential independent prognostic marker for gastric carcinoma
	high KLK11 but not the other KLK mRNA levels can be considered as strong independent favorable prognostic factor in this major ovarian cancer subtype
	potential biomarker for poor prognosis in patients with esophageal squamous cell carcinoma (ESCC)
Therapy target

ANIMAL & CELL MODELS