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FLASH GENE

Symbol

CCT5

contributors: mct/npt - updated : 19-05-2010

HGNC name	chaperonin containing TCP1, subunit 5 (epsilon)
HGNC id	1618

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SNSP sensory neuropathy with spastic paraplegia
Location	5p15.2      Physical location : 10.250.281 - 10.266.500
Synonym name	T-complex protein 1, epsilon subunit
Synonym symbol(s)	CCT-epsilon, CCTE, KIAA0098, TCP-1-epsilon

DNA

TYPE	functioning gene
STRUCTURE	16.22 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D5S630 - CCT5 - D5S478 - cen
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012073 11 - 3403 NP_036205 - 541 - Roobol (1995)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine small intestine     highly Reproductive female system uterus cervix   highly   male system testis     highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer

HOMOLOGY

Homologene

FAMILY	TCP-1 chaperonin family
	TF55/TCP-1 family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	assembled into a TCP1-ring complex (TRIC) and mediating ATP-dependent monomeric protein folding
	cytosolic molecular chaperone implicated especially in the biogenesis of cytoskeletal proteins by promoting the correct folding of the major ubiquitous cytoskeletal components, tubulin and actin (Roobol 1995)
	may be playing a role, in the folding of actin and tubulin
	required for maturation of sphingosine kinase 1 (Zebol 2009)
	CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a heterooligomeric complex (970kDa)

INTERACTION

DNA

RNA

small molecule

protein

interacting with PACRG

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SNSP

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS