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FLASH GENE

Symbol

INSL5

contributors: mct - updated : 03-11-2010

HGNC name	insulin-like 5
HGNC id	6088

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	like-sequence
STRUCTURE	3.52 kb     2 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005478 2 - 715 NP_005469 - 135 - 2009 19178384

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine rectum       intestine large intestine colon   highly Nervous brain diencephalon hypothalamus   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

protein matching the classical signature of the insulin superfamily with B and A chain regions

secondary structure

an insulin/relaxin-like fold with three helical segments that are braced by three disulfide bonds and enclose a hydrophobic core

HOMOLOGY

Homologene

FAMILY

relaxin/insulin family

CATEGORY

signaling hormone

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may have a role in gut contractility or in thymic development and regulation
	may be an endogenous ligand for RXFP4
	activates the relaxin family peptide receptor 4 with high potency and appears to be the endogenous ligand for this receptor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer of a B chain and an A chain linked by two disulfide bonds

INTERACTION

DNA

RNA

small molecule

protein	specific agonist for RXFP4, but not RXFP3 or RXFP1, endogenous ligand for RXFP4
	binds to and activates the G-protein coupled receptor, RXFP4

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS