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FLASH GENE
Symbol INSL5 contributors: mct - updated : 03-11-2010
HGNC name insulin-like 5
HGNC id 6088
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinerectum  
 intestinelarge intestinecolon highly
Nervousbraindiencephalonhypothalamus highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • protein matching the classical signature of the insulin superfamily with B and A chain regions
  • secondary structure
  • an insulin/relaxin-like fold with three helical segments that are braced by three disulfide bonds and enclose a hydrophobic core
  • HOMOLOGY
    Homologene
    FAMILY
  • relaxin/insulin family
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may have a role in gut contractility or in thymic development and regulation
  • may be an endogenous ligand for RXFP4
  • activates the relaxin family peptide receptor 4 with high potency and appears to be the endogenous ligand for this receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of a B chain and an A chain linked by two disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific agonist for RXFP4, but not RXFP3 or RXFP1, endogenous ligand for RXFP4
  • binds to and activates the G-protein coupled receptor, RXFP4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS