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FLASH GENE
Symbol INSL5 contributors: mct - updated : 03-11-2010
HGNC name insulin-like 5
HGNC id 6088
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • protein matching the classical signature of the insulin superfamily with B and A chain regions
    • secondary structure
  • an insulin/relaxin-like fold with three helical segments that are braced by three disulfide bonds and enclose a hydrophobic core
    • HOMOLOGY
    Homologene
    FAMILY
  • relaxin/insulin family
    • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may have a role in gut contractility or in thymic development and regulation
  • may be an endogenous ligand for RXFP4
  • activates the relaxin family peptide receptor 4 with high potency and appears to be the endogenous ligand for this receptor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of a B chain and an A chain linked by two disulfide bonds
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific agonist for RXFP4, but not RXFP3 or RXFP1, endogenous ligand for RXFP4
  • binds to and activates the G-protein coupled receptor, RXFP4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS