Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol INSL5 contributors: mct - updated : 03-11-2010
HGNC name insulin-like 5
HGNC id 6088
Location 1p31.3      Physical location : 67.263.424 - 67.266.939
Synonym name insulin-like peptide INSL5
Synonym symbol(s) MGC126695, MGC126697, PRO182, UNQ156
DNA
TYPE like-sequence
STRUCTURE 3.52 kb     2 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC35130 1p31.3 hypothetical protein MGC35130 KIAA1573 1p31.3 KIAA1573 protein KIAA1579 1p31.3 hypothetical protein FLJ10770 JAK1 1p31.3 Janus kinase 1 (a protein tyrosine kinase) LOC391045 1 similar to Solute carrier family 2, facilitated glucose transporter, member 3 (Glucose transporter type 3, brain) MRPS21P1 1p31.3 mitochondrial ribosomal protein S21 pseudogene AK3 1p31 adenylate kinase 3 DNAJC6 1pter-q31.3 DnaJ (Hsp40) homolog, subfamily C, member 6 LEPR 1p31 leptin receptor PDE4B 1p31 phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) DKFZp761D221 1p31.3 hypothetical protein DKFZp761D221 FLJ40873 1p31.3 hypothetical protein FLJ40873 INSL5 1p31.1-p22.3 insulin-like 5 FLJ23129 1p31.3 hypothetical protein FLJ23129 MI-ER1 1p31.3 mesoderm induction early response 1 SLC35D1 1p32-p31 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 IL23R 1p31.3-p31.2 interleukin-23 receptor IL12RB2 1p31.3-p31.2 interleukin 12 receptor, beta 2 PAI-RBP1 1p31-p22 PAI-1 mRNA-binding protein LOC391046 1 similar to heterogeneous nuclear ribonucleoprotein C isoform b; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein GADD45A 1p31.2-p31.1 growth arrest and DNA-damage-inducible, alpha GNG12 1p33-p31 guanine nucleotide binding protein (G protein), gamma 12 LOC391047 1 similar to NAD-dependent deacetylase sirtuin 5 (SIR2-like protein 5) ARHI 1p31 ras homolog gene family, member I FLJ23091 1p31.2 putative NFkB activating protein 373 LOC149224 1p31.2 similar to 40S ribosomal protein S7 (S8) RPE65 1p31 retinal pigment epithelium-specific protein 65kDa SDP35 1p31.2 cell cycle control protein SDP35 AF357533 1q31.3 thioredoxin 1 pseudogene 6 LOC388639 1 LOC388639
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 715 - 135 - 2009 19178384
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinerectum  
 intestinelarge intestinecolon highly
Nervousbraindiencephalonhypothalamus highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • protein matching the classical signature of the insulin superfamily with B and A chain regions
  • secondary structure
  • an insulin/relaxin-like fold with three helical segments that are braced by three disulfide bonds and enclose a hydrophobic core
  • HOMOLOGY
    Homologene
    FAMILY
  • relaxin/insulin family
  • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may have a role in gut contractility or in thymic development and regulation
  • may be an endogenous ligand for RXFP4
  • activates the relaxin family peptide receptor 4 with high potency and appears to be the endogenous ligand for this receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of a B chain and an A chain linked by two disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific agonist for RXFP4, but not RXFP3 or RXFP1, endogenous ligand for RXFP4
  • binds to and activates the G-protein coupled receptor, RXFP4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS