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FLASH GENE

Symbol

IGSF9B

contributors: mct - updated : 01-12-2020

HGNC name	immunoglobulin superfamily, member 9B
HGNC id	32326

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       lowly Nervous brain       highly Homo sapiens   spinal cord         Reproductive female system ovary     lowly   male system testis     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

IGSF9 family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION

basic FUNCTION	brain-specific, homophilic adhesion molecule that is strongly expressed in GABAergic interneurons
	IGSF9B is a key regulator of inhibition in the amygdala
	PRICKLE2 and IGSF9B coordinately regulate the cytoarchitecture of the axon initial segment

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	IGSF9B was linked to neuroligin 2, an inhibitory synaptic adhesion molecule coupled to gephyrin, via the multi-PDZ protein MAGI2
	PRICKLE2 regulates ANK3 distribution by controlling the proper localization of IGSF9B

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to multiple sclerosis (MS)

Variant & Polymorphism SNP	SNP rs10894768, which is positioned in IGSF9B (immunoglobulin superfamily member 9B) was associated with benign phenotype of MS

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry     IGSF9B-expressing synapses in the centromedial amygdala (CeM) may represent a target for anxiolytic therapies

ANIMAL & CELL MODELS