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FLASH GENE
Symbol IGSF9B contributors: mct - updated : 01-12-2020
HGNC name immunoglobulin superfamily, member 9B
HGNC id 32326
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY IGSF9 family
CATEGORY adhesion
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • brain-specific, homophilic adhesion molecule that is strongly expressed in GABAergic interneurons
  • IGSF9B is a key regulator of inhibition in the amygdala
  • PRICKLE2 and IGSF9B coordinately regulate the cytoarchitecture of the axon initial segment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IGSF9B was linked to neuroligin 2, an inhibitory synaptic adhesion molecule coupled to gephyrin, via the multi-PDZ protein MAGI2
  • PRICKLE2 regulates ANK3 distribution by controlling the proper localization of IGSF9B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis (MS)
    Variant & Polymorphism SNP
  • SNP rs10894768, which is positioned in IGSF9B (immunoglobulin superfamily member 9B) was associated with benign phenotype of MS
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    IGSF9B-expressing synapses in the centromedial amygdala (CeM) may represent a target for anxiolytic therapies
    ANIMAL & CELL MODELS