Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IGSF9B contributors: mct - updated : 01-12-2020
HGNC name immunoglobulin superfamily, member 9B
HGNC id 32326
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 17159 - 1437 - 2012 23251661
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   lowly
Nervousbrain   highly Homo sapiens
 spinal cord    
Reproductivefemale systemovary  lowly
 male systemtestis  lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY IGSF9 family
CATEGORY adhesion
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • brain-specific, homophilic adhesion molecule that is strongly expressed in GABAergic interneurons
  • IGSF9B is a key regulator of inhibition in the amygdala
  • PRICKLE2 and IGSF9B coordinately regulate the cytoarchitecture of the axon initial segment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IGSF9B was linked to neuroligin 2, an inhibitory synaptic adhesion molecule coupled to gephyrin, via the multi-PDZ protein MAGI2
  • PRICKLE2 regulates ANK3 distribution by controlling the proper localization of IGSF9B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis (MS)
    Variant & Polymorphism SNP
  • SNP rs10894768, which is positioned in IGSF9B (immunoglobulin superfamily member 9B) was associated with benign phenotype of MS
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    IGSF9B-expressing synapses in the centromedial amygdala (CeM) may represent a target for anxiolytic therapies
    ANIMAL & CELL MODELS