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FLASH GENE
Symbol IGSF9B contributors: mct - updated : 01-12-2020
HGNC name immunoglobulin superfamily, member 9B
HGNC id 32326
Location 11q25      Physical location : 133.785.185 - 133.826.880
Genatlas name protein turtle homolog B
Synonym name
  • fibronectin III
  • MIR4697 host gene (non-protein coding)
  • long intergenic non-protein coding RNA 947
    • Synonym symbol(s) KIAA1030, LINC00947, MIR4697HG, FLJ41855, MGC117185, MGC126740, DKFZp434N079, DKFZp686C19121
    DNA
    TYPE functioning gene
    STRUCTURE 60.53 kb     20 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 17159 - 1437 - 2012 23251661
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   lowly
    Nervousbrain   highly Homo sapiens
     spinal cord    
    Reproductivefemale systemovary  lowly
     male systemtestis  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY IGSF9 family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • brain-specific, homophilic adhesion molecule that is strongly expressed in GABAergic interneurons
  • IGSF9B is a key regulator of inhibition in the amygdala
  • PRICKLE2 and IGSF9B coordinately regulate the cytoarchitecture of the axon initial segment
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IGSF9B was linked to neuroligin 2, an inhibitory synaptic adhesion molecule coupled to gephyrin, via the multi-PDZ protein MAGI2
  • PRICKLE2 regulates ANK3 distribution by controlling the proper localization of IGSF9B
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to multiple sclerosis (MS)
    Variant & Polymorphism SNP
  • SNP rs10894768, which is positioned in IGSF9B (immunoglobulin superfamily member 9B) was associated with benign phenotype of MS
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    IGSF9B-expressing synapses in the centromedial amygdala (CeM) may represent a target for anxiolytic therapies
    ANIMAL & CELL MODELS