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FLASH GENE

Symbol

IRF3

contributors: mct/pgu - updated : 19-10-2018

HGNC name	interferon regulatory factor 3
HGNC id	6118

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrant expression in lung cancer tumoral     --other   aberrant splicing of IRF3 in hepatocellular carcinoma (HCC) contributes to the defect in IFN-mediated antiviral defenses

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Irf3(-/-) mice showed a pathogen-specific increase in acute mortality, bacterial burden, abscess formation and renal damage compared to wild type mice
	Irf3-deficient mice exhibited lethal defects in the inflammatory and recovery phases of the colitis, accompanied by marked defects in the gene induction for thymic stromal lymphopoietin (TSLP)