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FLASH GENE
Symbol IRF3 contributors: mct/pgu - updated : 19-10-2016
HGNC name interferon regulatory factor 3
HGNC id 6118
ANIMAL & CELL MODELS
  • Irf3(-/-) mice showed a pathogen-specific increase in acute mortality, bacterial burden, abscess formation and renal damage compared to wild type mice
  • Irf3-deficient mice exhibited lethal defects in the inflammatory and recovery phases of the colitis, accompanied by marked defects in the gene induction for thymic stromal lymphopoietin (TSLP)