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FLASH GENE
Symbol IRF3 contributors: mct/pgu - updated : 19-10-2016
HGNC name interferon regulatory factor 3
HGNC id 6118
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
aberrant expression in lung cancer
tumoral     --other  
aberrant splicing of IRF3 in hepatocellular carcinoma (HCC) contributes to the defect in IFN-mediated antiviral defenses
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Irf3(-/-) mice showed a pathogen-specific increase in acute mortality, bacterial burden, abscess formation and renal damage compared to wild type mice