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FLASH GENE

Symbol

SIGLEC5

contributors: mct - updated : 23-01-2007

HGNC name	sialic acid binding Ig-like lectin 5
HGNC id	10874

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.4      Physical location : 52.114.781 - 52.133.727
Synonym name	cell differentiation antigen CD33-like 2
	obesity-binding protein 2
	CD170 antigen
Synonym symbol(s)	CD33L2, OB-BP2, OBBP2, CD170, SIGLEC-5

DNA

TYPE	functioning gene
STRUCTURE	18.95 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	cen - D19S425 - COX6B1 - D19S208 - D19S224 - SCN1B - D19S228 - LGALS7 - D19S421 - RPS16 - MST1 - D19S223 - RPS19 - D19S217 - ERCC1 - D19S219 - D19S606 - FUT1 - SNRP70 - D19S907 - SIGLEC5 - FPRL1 - D19S571 - D19S927 - D19S418 - qter
Authors	GeneMap (98)

regionally located

clustering with SIGLEC3/CD33 related subset on SIGLECs on chromosome 19

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003830 9 splicing 2498 NP_003821 - 551 - 1998 9731071 variant 3 - - - isoform 3 - - - 2002 12358929 also called SIGLEC5 3L one long cytoplasmic tail and three extracellular domains variant 2 - - - isoform 2 - - - 2002 12358929 also called SIGLEC5 3C soluble isoform with three extracellular domains variant 4 - - - isoform 4 - - splen,thymus,lymph node,peripheral leukocytes,bone marrow,fetal lung and liver 2002 12358929 also called SIGLEC5 4L long cytoplasmic tail and four extracellular domains variant 5 - - - isoform 5 - - - 2002 12358929 also called SIGLEC5 4S short tail and four extracellular domains

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx         Lymphoid/Immune spleen         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil

cell lineage	myeloid cells lineage
cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two tyrosine-based motifs in its cytoplasmic tail implicated in signaling functions
	four Ig-like domains
	three immunoglobulin-like C2-type domains
	one immunoglobulin-like V-type domain
	one N-terminal IgV-SET domain
	three IgC2-SET domains
	a cytoplasmic domain with ITIM (immunoreceptor tyrosine based inhibitory) motifs forming disulfide-linked homodimers and SAP motifs which regulate cell signaling

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	immunoglobulin superfamily
	SIGLEC (sialic acid binding Ig-like lectin) family

CATEGORY

adhesion , antigen , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	putative adhesion molecule mediating sialic-acid dependent binding to cells
	playing a role in cell/cell interactions following microbial exposure
	can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation
	plays a distinctive and important role in regulating eosinophil accumulation and survival

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

member of CD33-related siglec subgroup of sialic acid binding Ig-like lectins

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in acute myeloid leukemia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS