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FLASH GENE
Symbol SIGLEC5 contributors: mct - updated : 23-01-2007
HGNC name sialic acid binding Ig-like lectin 5
HGNC id 10874
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two tyrosine-based motifs in its cytoplasmic tail implicated in signaling functions
  • four Ig-like domains
  • three immunoglobulin-like C2-type domains
  • one immunoglobulin-like V-type domain
  • one N-terminal IgV-SET domain
  • three IgC2-SET domains
  • a cytoplasmic domain with ITIM (immunoreceptor tyrosine based inhibitory) motifs forming disulfide-linked homodimers and SAP motifs which regulate cell signaling
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • SIGLEC (sialic acid binding Ig-like lectin) family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative adhesion molecule mediating sialic-acid dependent binding to cells
  • playing a role in cell/cell interactions following microbial exposure
  • can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation
  • plays a distinctive and important role in regulating eosinophil accumulation and survival
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of CD33-related siglec subgroup of sialic acid binding Ig-like lectins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS