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FLASH GENE
Symbol SIGLEC5 contributors: mct - updated : 23-01-2007
HGNC name sialic acid binding Ig-like lectin 5
HGNC id 10874
DNA
TYPE functioning gene
STRUCTURE 18.95 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - D19S425 - COX6B1 - D19S208 - D19S224 - SCN1B - D19S228 - LGALS7 - D19S421 - RPS16 - MST1 - D19S223 - RPS19 - D19S217 - ERCC1 - D19S219 - D19S606 - FUT1 - SNRP70 - D19S907 - SIGLEC5 - FPRL1 - D19S571 - D19S927 - D19S418 - qter
Authors GeneMap (98)
regionally located clustering with SIGLEC3/CD33 related subset on SIGLECs on chromosome 19
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 2498 - 551 - 1998 9731071
- - - - - - 2002 12358929
  • also called SIGLEC5 3L
  • one long cytoplasmic tail and three extracellular domains
  • - - - - - - 2002 12358929
  • also called SIGLEC5 3C
  • soluble isoform with three extracellular domains
  • - - - - - splen,thymus,lymph node,peripheral leukocytes,bone marrow,fetal lung and liver 2002 12358929
  • also called SIGLEC5 4L
  • long cytoplasmic tail and four extracellular domains
  • - - - - - - 2002 12358929
  • also called SIGLEC5 4S
  • short tail and four extracellular domains
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx    
    Lymphoid/Immunespleen    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    cell lineage myeloid cells lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two tyrosine-based motifs in its cytoplasmic tail implicated in signaling functions
  • four Ig-like domains
  • three immunoglobulin-like C2-type domains
  • one immunoglobulin-like V-type domain
  • one N-terminal IgV-SET domain
  • three IgC2-SET domains
  • a cytoplasmic domain with ITIM (immunoreceptor tyrosine based inhibitory) motifs forming disulfide-linked homodimers and SAP motifs which regulate cell signaling
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • SIGLEC (sialic acid binding Ig-like lectin) family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative adhesion molecule mediating sialic-acid dependent binding to cells
  • playing a role in cell/cell interactions following microbial exposure
  • can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation
  • plays a distinctive and important role in regulating eosinophil accumulation and survival
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of CD33-related siglec subgroup of sialic acid binding Ig-like lectins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS