basic FUNCTION
| promoting the GSK3B dependent phosphorylation of beta catenin (CTNNB1) |
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negatively regulates both expansion of osteoprogenitors and maturation of osteoblasts through its modulation on Wnt/beta-catenin signaling |
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promotes centrosome cohesion by phosphorylating CTNNB1 at centrosomes (Hadjihannas 2010) |
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negative regulator of beta-catenin, localizes at the centrosomes by binding to the centriole-associated component CEP250 |
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essential for normal kinetics of remyelination ( |
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serves as a negative regulator of canonical WNT signaling in normal cells |
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tumor suppressor function of AXIN2 in normal cells is most likely coopted by cancer cells to promote, rather than suppress, key aspects of the cancer progression program |
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RUNX2 and AXIN2 regulate craniofacial development and skeletal maintenance |
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nuclear AXIN2 functions likely as a rheostat to control MYC expression in response to WNT/CTNNB1 signaling |
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AXIN1 and AXIN2 do not have equivalent functions in satellite cells, but are both involved in repression of WNT/CTNNB1 signalling to maintain proliferation and contribute to controlling timely myogenic differentiation |
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critical role for AXIN2 during ocular development, likely by restricting the activity of the WNT/CTNNB1 pathway |
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AXIN2-expressing cells produce a source of WNT that acts in an autocrine manner to modulate reparative dentinogenesis |
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AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development |