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FLASH GENE

Symbol

CDH15

contributors: mct/npt - updated : 07-01-2009

HGNC name	cadherin 15, type 1, M-cadherin (myotubule)
HGNC id	1754

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 14 - 2875 - 814 - Hollnagel (2002)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain hindbrain cerebellum     Reproductive female system placenta

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Muscular myoblast

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal hydrophobic domain
	five extracellular cadherin repeats
	four cysteines in the most proximal
	a transmembrane segment (TM)
	a highly conserved cytoplasmic tail required for interactions

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION

plasma membrane,junction,tight

basic FUNCTION

transmembrane glycoprotein component of adherens junction, playing an essential role in the control of morphogenetic processes

CELLULAR PROCESS	cell life, differentiation
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	myogenesis
	terminal muscle cells differentiation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	heterophilic, calcium dependent interactions
	interacting by its C terminus with the cytoskeleton via beta-catenin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in breast carcinoma (see TSG16H) constitutional       loss of function in patients with mild to severe intellectual disability

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS