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FLASH GENE
Symbol CDH15 contributors: mct/npt - updated : 07-01-2009
HGNC name cadherin 15, type 1, M-cadherin (myotubule)
HGNC id 1754
DNA
TYPE functioning gene
STRUCTURE 23.74 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see TSG16H
Physical map
ZFPM1 16q24.3 zinc finger protein, multitype 1 LOC124245 16q24.3 hypothetical protein BC001584 IL17C 16q24 interleukin 17C CYBA 16q24.2 cytochrome b-245, alpha polypeptide MVD 16q24.2 mevalonate (diphospho) decarboxylase SNAI3 16q24.3 snail homolog 3 (Drosophila) MGC2647 16q24.3 hypothetical zinc finger protein MGC2647 LOC388307 16 similar to LOC348180 protein LOC348180 16q24.3 hypothetical protein LOC348180 KIAA0233 16q24.3 hypothetical protein LOC348180 FLJ40448 16q24.3 hypothetical protein FLJ40448 CDT1 16q24.3 DNA replication factor APRT 16q24.3 adenine phosphoribosyltransferase GALNS 16q24.2 galactosamine (N-acetyl)-6-sulfate sulfatase (Morquio syndrome, mucopolysaccharidosis type IVA) LOC51693 16q24.3 unknown LOC390748 16 similar to putative polyA-binding protein PABPN2/ePABP2 CBFA2T3 16q24.3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 LOC390749 16 LOC390749 LOC197322 16q24.3 hypothetical protein LOC197322 FLJ36701 16q24.3 hypothetical protein FLJ36701 CDH15 16q24.3 cadherin 15, M-cadherin (myotubule) LOC388308 16 similar to Brain-type organic cation transporter FLJ31875 16q24.3 hypothetical protein FLJ31875 ANKRD11 16q24.3 ankyrin repeat domain 16 LOC390750 16 similar to Hypothetical protein CBG22662 LOC390751 16 LOC390751 SPG7 16q24.3 spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) RPL13 16q24.3 ribosomal protein L13 CPNE7 16q24.3 copine VII DPEP1 16q24.3 dipeptidase 1 (renal) PCOLN3 16q24.3 procollagen (type III) N-endopeptidase FLJ31606 16q24.3 hypothetical protein FLJ31606 LOC388309 16 LOC388309 CDK10 16q24.3 cyclin-dependent kinase (CDC2-like) 10 MGC26885 16q24.3 hypothetical protein MGC26885 C16orf7 16q24 chromosome 16 open reading frame 7 ZFP276 16q24.3 zinc finger protein 276 homolog (mouse) FANCA 16q24.3 Fanconi anemia, complementation group A
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2875 - 814 - Hollnagel (2002)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrainhindbraincerebellum  
Reproductivefemale systemplacenta   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyoblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats
  • four cysteines in the most proximal
  • a transmembrane segment (TM)
  • a highly conserved cytoplasmic tail required for interactions
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • transmembrane glycoprotein component of adherens junction, playing an essential role in the control of morphogenetic processes
    • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • myogenesis
  • terminal muscle cells differentiation
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • heterophilic, calcium dependent interactions
  • interacting by its C terminus with the cytoskeleton via beta-catenin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in breast carcinoma (see TSG16H)
    constitutional       loss of function
    in patients with mild to severe intellectual disability
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS