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FLASH GENE
Symbol CDH15 contributors: mct/npt - updated : 07-01-2009
HGNC name cadherin 15, type 1, M-cadherin (myotubule)
HGNC id 1754
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats
  • four cysteines in the most proximal
  • a transmembrane segment (TM)
  • a highly conserved cytoplasmic tail required for interactions
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • transmembrane glycoprotein component of adherens junction, playing an essential role in the control of morphogenetic processes
    • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • myogenesis
  • terminal muscle cells differentiation
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • heterophilic, calcium dependent interactions
  • interacting by its C terminus with the cytoskeleton via beta-catenin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in breast carcinoma (see TSG16H)
    constitutional       loss of function
    in patients with mild to severe intellectual disability
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS