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FLASH GENE

Symbol

KIF1C

contributors: mct/npt/shn - updated : 28-12-2018

HGNC name	kinesin family member 1C
HGNC id	6317

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SPAX2

Susceptibility

to autoimmune orchitis

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	kif1C(-/-) mice are viable and showed no obvious abnormalities
	no significant difference in the distribution of the Golgi apparatus or in the transport from the Golgi apparatus to the endoplasmic reticulum in fibroblasts from kif1C(-/-) mice
	Expression of mutation constructs or small interfering RNA-/short hairpin RNA-based depletion of KIF1C resulted in decreased podosome dynamics and ultimately in podosome deficiency