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FLASH GENE
Symbol FDX1 contributors: mct - updated : 20-11-2017
HGNC name ferredoxin 1
HGNC id 3638
Location 11q22.3      Physical location : 110.300.593 - 110.335.604
Synonym name
  • adrenodoxin
  • hepatoredoxin
  • adrenal ferredoxin
  • mitochondrial adrenodoxin
    • Synonym symbol(s) ADX, FDX, YAH1, LOH11CR1D
    DNA
    TYPE functioning gene
    STRUCTURE 35.01 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - (D11S384 /ACAT1 ) - D11S535 ,D11S2179 - D11S1294 - D11S2180 ,D11S1818 - D11S1897 - D11S2021 - D11S927 - D11S1300 - FDX1 - D11S1391 - D11S1893 - D11S996E , CRYAB , D11S1347 - D11S424 - D11S897 - NCAM1 - qter
    Authors Arai (96)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3236 5.85 184 - 2015 26370181
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 2fe-2s ferredoxin-type domain
    • HOMOLOGY
    Homologene
    FAMILY
  • adrenodoxin/putidaredoxin family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus
    text
  • present in the matrix of human mitochondria
    • basic FUNCTION
  • small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450
  • mitochondrial electron transfer protein, is able to support reactions catalyzed by human microsomal P450 (Pechurskaya 2007)
  • participating in the synthesis of thyroid hormones
  • able to reduce mitochondrial cytochrome P450 (Sheftel 2010)
  • can only reduce mitochondrial CYP enzymes that are essential in adrenal steroidogenesis, bile acid formation, and vitamin D synthesis (Sheftel 2010)
  • is an iron-sulfur protein that is involved in various metabolic processes, including steroid hormone synthesis in mammalian tissues
  • transcription of FDX1 is regulated by the NR5A family and cAMP signaling, and participates in steroid hormone production in ovarian granulosa cells
  • TNFSF13 and FDX1 have potential roles in IgA nephropathy (IgAN)
  • FDX1L, FDX1, play an important role as an electron donor in iron-sulfur (Fe-S) cluster biosynthesis
  • FDX1L, FDX1 can function in Fe-S cluster assembly
  • has an only weak effect on ferric and ferrous CO states, but it has a relatively stronger impact on the Fe-O-O fragments of the functionally relevant oxy complexes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 2fe-2s cluster
    • protein
  • interference with any of the three related genes, FDX1, FDX1L or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis
  • NR5A1 could bind to the FDX1 promoter in differentiated hMSCs
  • supports steroid biosynthesis in steroidogenic cells through electron transfer to the rate-limiting steroidogenic enzyme, CYP11A1
  • mitochondrial cytochrome P450s require adrenodoxin (FDX1) and adrenodoxin reductase (FDXR)
  • JUN may cooperate with other partners to regulate FDX1 in Leydig cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS