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FLASH GENE

Symbol

CXCL11

contributors: mct/npt - updated : 16-09-2009

HGNC name	chemokine (C-X-C motif) ligand 11
HGNC id	10638

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	contained in a minicluster on chromosome
STRUCTURE	2.39 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - IL8 - CXCL1 /PPBP /PF4 - CXCL5 /CXCL6 - CXCL2 /CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
Authors	O'Donovan(99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 4 - - - isoform 4 - 68 - Cox (2008) also called CXCL11-(5-73) CXCR3 antagonist and interestingly shows enhanced affinity to heparin NM_005409 4 - 1493 NP_005400 - 94 - Cole (1998) variant 2 - - - isoform 2 - 58 - Cox (2008) also called CXCL11-(5-63) variant 3 - - - isoform 3 - 53 - Cox (2008) also called CXCL11-(5-58)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly   salivary gland         Reproductive female system breast       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Epithelial secretory glandular endocrine   Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune natural killer Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Cxcl11

intraspecies

homolog to MIG,INP10,highly

Homologene

FAMILY	intercrine alpha (chemokine CxC) family
	(small inducible cytokine,chemokine alpha), CXC subfamily

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may be playing an important role in CNS diseases which involve T cell recruitment
	key ligand in the CXCR3 signaling system for wound repair, promoting re-epithelialization and modulating the maturation of the superficial dermis (Yates 2008)
	matrix metalloproteinase processing of CXCL11 results in loss of chemoattractant activity and altered glycosaminoglycan binding (Cox 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	most dominant physiological inducer of adhesion, migration, and internalization of CXCR3 (Dagan-Berger 2006)
	ACKR3 binds the chemokines CXCL12 and CXCL11

cell & other

REGULATION

induced by

IFN gamma (IFN-gamma promotes implantation by stimulating endometrial epithelial cells (EEC) to produce CXCL11, which induces migration of trophoblast cells and T cells, proliferation of endometrial stromal cells, and apoptosis of EEC) (Hirota 2006)

Other

cleavage of the N-terminal two residues by DPP8

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the salivary glands of Sjögren syndrome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS