| basic FUNCTION
| overexpression may be an early event in the pathogenesis of multiple myeloma involving IL6 production |
|
play dual roles as activators of Notch receptor signaling and as receptors that mediate nuclear signaling events via gamma-secretase-generated cytoplasmic domain |
|
critical role for JAG2-Notch signaling in the maintenance of proliferating neural precursors in a discrete compartment of the neural tube during the continuing growth and development of the vertebrate nervous system  |
|
JAG2-Notch axis plays a crucial role in dendritic cells-mediated NK cell cytotoxicity |
|
can regulate the expression of cytokines that can promote antitumor immunity |
|
its expression by dendritic cells is not sufficient or required for Th2 cell differentiation |
|
IRF6 and the Notch ligand JAG2 function in convergent molecular pathways during oral epithelial differentiation |
|
like Delta-like ligands, induces T-lineage differentiation and inhibits B-cell and myeloid development |
|
unexpected functional similarity between JAG2 and the Delta-like ligands |
|
hypoxic induction of JAG2 in tumor cells mediates a hypoxia-regulated cross-talk between tumor and endothelial cells |
|
JAG2 is a key regulator of the timely and ordered generation of two of the defining cell types in the spinal cord, motor neurons (MNs) and oligodendrocyte progenitors (OLPs) |
|
enhances immunomodulatory activity in adipose derived mesenchymal stem cells |
|
JAG2 implicated in promoting aggressiveness of colorectal cancer (CRC) |
|
JAG2 is involved in the regulation of migration and invasion of colon cancer cells without affecting cell proliferation |
|
involved in the regulation of migration and invasion independent of the canonical NoTCH1 signaling pathway |
