motifs/domains
| a N terminal actin-binding domain, N terminus containing two calponin-homology (CH) domains that bind actin, a plakin domain, and a long spectrin-repeat rod domain that confers flexibility  |
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a central rod region with 37 spectrin-like repeats |
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an intrinsic actin-regulated ATPase domain |
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a SH3 domain |
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ATPase domain that is required for microtubule tracking along actin fibers toward focal adhesions |
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C terminus functions as a Micotubule binding domain and contains two calcium-binding EF-hand domains, a zinc-binding GAR (growth-arrest specific 2 or Gas2-related) domain, a positively charged Gly-Ser-Arg (GSR) region, and an EB1-binding SxIP domain |
| basic FUNCTION
| forming bridges between different cytoskeletal elements through specialized modular domains |
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stabilizing actin at sites where microtubules and microfilaments meet, and essential integrator of microtubule dynamics |
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multidomain protein that can associate with microfilaments and microtubules |
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may be playing a role in the Wnt signaling pathway |
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can function as an ATPase, and, importantly, it behaves as an actin-regulated rather than microtubules- or calcium-regulated ATPase |
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having particular functions in establishing and maintaining proper cytoskeletal coordination during cell movement |
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MACF1 and SHOX2 regulate the organisation of neuronal microtubules, a role dependent on both the F-actin- and microtubule-binding domains |
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having functions in regulating dynamic interactions between microtubules and F-actin to sustain directional cell movement |
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MACF1 and SHOX2 regulate the organisation of neuronal microtubules, a role dependent on both the F-actin- and microtubule-binding domains |
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required and sufficient for MT capture, probably via its ability to interact with ANKS1B at MT ends |
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seems to use two different modes of action associated with distinct functions: displacement along actin might require motor-like activity, whereas MT capture might not |
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integrates signaling, cytoskeletal dynamics, and polarized locomotion of somatic stem cells |
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regulates MT growth as well as the dynamics of focal adhesions associated with F-actin |
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critical in CNS development |
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ELMO1 and MACF1 cooperate to promote the formation of membrane protrusions |
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role for MACF1 in cardiomyocyte microtubule distribution and in adaptation to hemodynamic overload |
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novel role for MACF1 in neurite differentiation that is critical to the creation of neuronal connectivity in the developing brain |
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plays a role in the coordination of microtubules and actin in multiple cellular processes |
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is an important regulator of apico-basal polarity in mammalian intestinal cells and that a radial centrosome-centered microtubule organization can act as an inhibitor of epithelial polarity |
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play critical roles in many cytoskeleton-related processes |
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may play a part in neuromuscular disorders and have a neuroprotective role in the optic nerve |
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plays an essential function in various cellular processes, including cell proliferation, migration, signaling transduction and embryo development |
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large spectraplakin protein known to have crucial roles in regulating cytoskeletal dynamics, cell migration, growth, and differentiation |
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control of MACF1 levels by HECTD1 modulates likely epithelial-to-mesenchymal transition (EMT) and the efficiency of metastasis |
