basic FUNCTION
| an antagonist of Tgfbeta family proteins |
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a candidate tumor suppressor involved in promoting serine-protease-mediated cell death |
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potential role as a predictive factor of clinical response to chemotherapy |
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a putative role in extracellular matrix homeostasis |
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decreases TGFB signaling through its protease activity and might play a pivotal role in human cerebral small-vessel disease |
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might likely function as a MAPT protease |
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plays a detrimental role in the pathogenesis of intervertebral disc (IVD) degeneration |
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promotes IVD degeneration through the proteolytic cleavage of fibronectin and subsequent activation of resident disc cells |
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likely a central role for HTRA1 in joint degeneration through its proteolytic actions on ECM components |
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HTRA1 and FGF8 may function coordinately in the common FGF signaling pathway |
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antagonizes TGFB1 signaling, and plays a key role in the regulation of bone formation |
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is produced as a secreted protein during osteoclastogenesis, and negatively regulates osteoblast differentiation |
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may likely mediate the fine tuning of paracrine and autocrine regulations during bone remodeling processes |
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HTRA1 and HTRA3 are crucial for trophoblast-decidual cell interaction in the control of trophoblast invasion |
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play a modulatory role in metastasis of hepatocellular carcinoma (HCC), and its expression was closely related to EMT, which might be a potential mechanism underlying metastasis of HCC |
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HTRA1, HTRA2, HTRA3, HTRA4 function as important modulators of many physiological processes, including maintenance of mitochondrial homeostasis, cell signaling and apoptosis |