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| References | OMIM | Gene | GeneReviews | HGMD | HGNC |
| GENATLAS PHENOTYPE |
| last update : 19-03-2009 |
| Symbol | ARMD7 |
| Location | 10q26.13 |
| Name | age-related macular degeneration, 7 |
| Corresponding gene | HTRA1 |
| Other symbol(s) | ARMDH |
| Main clinical features | loss of central vision as AMD affect the macular region of the eye |
| Genetic determination | |
| Function/system disorder | eye |
| Type | susceptibility factor |
| Mechanism(s) |
| Gene mutation | Chromosome rearrangement | Effect | Comments | |
|---|---|---|---|---|
| other | variant rs11200638 (HTRA1 promoter, -512 bp) |
| Remark(s) | AMD has a multifactorial aetiology with both genetic and environmental factors (age and smoking) ; the two 10q26 SNP in HTRA1 and ARMS2 contribute equally to disease risk (Francis,08) |