| 1 | CARASIL, HTRA1
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| A CARASIL Patient from Americas with Novel Mutation and Atypical Features: Case Presentation and Literature Review.
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| Ibrahimi M, Nozaki H, Lee A, Onodera O, Reichwein R, Wicklund M, El-Ghanem M.
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| Cerebrovasc Dis 44(3-4):135-140. doi: 10.1159/000477358. [Epub ahead of print]
2017
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| 2 | HTRA1, HTRA2, HTRA3, HTRA4
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| Structural insights into the activation mechanisms of human HtrA serine proteases.
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| Zurawa-Janicka D, Wenta T, Jarzab M, Skorko-Glonek J, Glaza P, Gieldon A, Ciarkowski J, Lipinska B.
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| Arch Biochem Biophys 621:6-23. doi: 10.1016/j.abb.2017.04.004. Epub 2017 Apr 7. Review.
2017
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| 3 | CARASIL, HTRA1
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| [Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL)].
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| Uemura M, Nozaki H, Onodera O.
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| Brain Nerve 69(1):25-33. doi: 10.11477/mf.1416200631. Japanese.
2017
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| 4 | CARASIL, HTRA1
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| Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL.
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| Nozaki H, Kato T, Nihonmatsu M, Saito Y, Mizuta I, Noda T, Koike R, Miyazaki K, Kaito M, Ito S, Makino M, Koyama A, Shiga A, Uemura M, Sekine Y, Murakami A, Moritani S, Hara K, Yokoseki A, Kuwano R, Endo N, Momotsu T, Yoshida M, Nishizawa M, Mizuno T, Onodera O.
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| Neurology 86(21):1964-74. doi: 10.1212/WNL.0000000000002694. Epub 2016 Apr 27.
2016
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| 5 | HTRA1
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| HTRA1 Overexpression Induces the Exudative Form of Age-related Macular Degeneration.
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| Iejima D, Nakayama M, Iwata T.
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| J Stem Cells 10(3):193-203.
2015
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| 6 | HTRA1
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| HtrA1 regulates epithelial-mesenchymal transition in hepatocellular carcinoma.
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| Zhu F, Duan YF, Bao WY, Liu WS, Yang Y, Cai HH.
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| Biochem Biophys Res Commun 467(3):589-94. doi: 10.1016/j.bbrc.2015.09.105. Epub 2015 Sep 25.
2015
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| 7 | HTRA1
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| Serum HtrA1 is differentially regulated between early-onset and late-onset preeclampsia.
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| Teoh SS, Zhao M, Wang Y, Chen Q, Nie G.
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| Placenta 36(9):990-5. doi: 10.1016/j.placenta.2015.07.001. Epub 2015 Jul 8.
2015
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| 8 | HTRA1
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| Decrease in serine protease HtrA1 expression correlates with grade and recurrence in meningiomas.
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| Önder E, Arıkök AT, Seçkin H, Alper M.
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| Adv Med Sci 60(1):139-43. doi: 10.1016/j.advms.2015.01.005. Epub 2015 Jan 23.
2015
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| 9 | HTRA1
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| Abnormal development of placenta in HtrA1-deficient mice.
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| Hasan MZ, Ikawati M, Tocharus J, Kawaichi M, Oka C.
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| Dev Biol 397(1):89-102. doi: 10.1016/j.ydbio.2014.10.015. Epub 2014 Oct 27.
2015
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| 10 | HTRA1, MMP20
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| MMP20 and ARMS2/HTRA1 Are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration
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| Yoshimura N; Nagahama Cohort Research Group
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| Ophthalmology Nov;122(11):2295-2302.e2. doi: 10.1016/j.ophtha.2015.07.032. Epub 2015 Sep 1 2015
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| 11 | HTRA1, HTRA3, HTRA4
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| Functional antagonism between high temperature requirement protein A (HtrA) family members regulates trophoblast invasion.
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| Chen YY, Chuang PY, Chen CP, Chiu YH, Lo HF, Cheong ML, Huang JY, Kuo PL, Chen H.
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| J Biol Chem 289(33):22958-68. doi: 10.1074/jbc.M114.576744. Epub 2014 Jul 7.
2014
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| 12 | HTRA1
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| Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium.
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| Kumar S, Berriochoa Z, Ambati BK, Fu Y.
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| Invest Ophthalmol Vis Sci 55(6):3842-50. doi: 10.1167/iovs.13-13111.
2014
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| 13 | HTRA1
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| HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation.
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| Wu X, Chim SM, Kuek V, Lim BS, Chow ST, Zhao J, Yang S, Rosen V, Tickner J, Xu J.
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| FEBS Lett 588(1):143-50. doi: 10.1016/j.febslet.2013.11.022. Epub 2013 Nov 21.
2014
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| 14 | HTRA1
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| Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.
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| Graham JR, Chamberland A, Lin Q, Li XJ, Dai D, Zeng W, Ryan MS, Rivera-Bermúdez MA, Flannery CR, Yang Z.
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| PLoS One 8(9):e74094. doi: 10.1371/journal.pone.0074094. eCollection 2013.
2013
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| 15 | HTRA1, LRP1
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| LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1.
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| Muratoglu SC, Belgrave S, Hampton B, Migliorini M, Coksaygan T, Chen L, Mikhailenko I, Strickland DK.
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| Arterioscler Thromb Vasc Biol 33(9):2137-46. doi: 10.1161/ATVBAHA.113.301893. Epub 2013 Jul 18.
2013
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| 16 | HTRA1
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| Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina.
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| Wang G, Dubovy SR, Kovach JL, Schwartz SG, Agarwal A, Scott WK, Haines JL, Pericak-Vance MA.
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| Exp Eye Res 112:102-5. doi: 10.1016/j.exer.2013.04.019. Epub 2013 May 3.
2013
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| 17 | HTRA1
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| Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.
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| Jacobo SM, Deangelis MM, Kim IK, Kazlauskas A.
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| Mol Cell Biol 33(10):1976-90. doi: 10.1128/MCB.01283-12. Epub 2013 Mar 11.
2013
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| 18 | HTRA1
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| Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration.
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| Tiaden AN, Klawitter M, Lux V, Mirsaidi A, Bahrenberg G, Glanz S, Quero L, Liebscher T, Wuertz K, Ehrmann M, Richards PJ.
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| J Biol Chem 287(25):21335-45. doi: 10.1074/jbc.M112.341032. Epub 2012 May 3.
2012
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| 19 | HTRA1, MAPT
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| Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.
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| Tennstaedt A, Pöpsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R, Ksiezak-Reding H, Tirniceriu AL, Egensperger R, Baldi A, Dehmelt L, Kaiser M, Huber R, Clausen T, Ehrmann M.
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| J Biol Chem 287(25):20931-41. doi: 10.1074/jbc.M111.316232. Epub 2012 Apr 25.
2012
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| 20 | FGF8, HTRA1
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| HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8.
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| Kim GY, Kim HY, Kim HT, Moon JM, Kim CH, Kang S, Rhim H.
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| Mol Cell Biol 32(21):4482-92. doi: 10.1128/MCB.00872-12. Epub 2012 Sep 4.
2012
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| 21 | CARASIL, HTRA1
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| A novel mutation in the HTRA1 gene causes CARASIL without alopecia.
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| Nishimoto Y, Shibata M, Nihonmatsu M, Nozaki H, Shiga A, Shirata A, Yamane K, Kosakai A, Takahashi K, Nishizawa M, Onodera O, Suzuki N.
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| Neurology 76(15):1353-5. No abstract available.
2011
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| 22 | HTRA1
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| Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1.
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| Shiga A, Nozaki H, Yokoseki A, Nihonmatsu M, Kawata H, Kato T, Koyama A, Arima K, Ikeda M, Katada S, Toyoshima Y, Takahashi H, Tanaka A, Nakano I, Ikeuchi T, Nishizawa M, Onodera O.
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| Hum Mol Genet 20(9):1800-10. Epub 2011 Feb 14.
2011
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| 23 | HTRA1
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| Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.
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| Yang Z, Tong Z, Chen Y, Zeng J, Lu F, Sun X, Zhao C, Wang K, Davey L, Chen H, London N, Muramatsu D, Salasar F, Carmona R, Kasuga D, Wang X, Bedell M, Dixie M, Zhao P, Yang R, Gibbs D, Liu X, Li Y, Li C, Li Y, Campochiaro B, Constantine R, Zack DJ, Campochiaro P, Fu Y, Li DY, Katsanis N, Zhang K.
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| PLoS Genet 6(2):e1000836.
2010
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| 24 | HTRA1
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| Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.
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| Hadley D, Orlin A, Brown G, Brucker AJ, Ho AC, Regillo CD, Donoso LA, Tian L, Kaderli B, Stambolian D.
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| Invest Ophthalmol Vis Sci 51(4):2191-6. Epub 2009 Nov 20.PMID: 19933195 2010
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| 25 | ARMS2, HTRA1
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| Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.
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| Hadley D, Orlin A, Brown G, Brucker AJ, Ho AC, Regillo CD, Donoso LA, Tian L, Kaderli B, Stambolian D.
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| Invest Ophthalmol Vis Sci. 51(4):2191-6. 2010
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| 26 | CARASIL, HTRA1
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| A missense HTRA1 mutation expands CARASIL syndrome to the Caucasian population.
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| Mendioroz M, Fernández-Cadenas I, Del Río-Espinola A, Rovira A, Solé E, Fernández-Figueras MT, García-Patos V, Sastre-Garriga J, Domingues-Montanari S, Alvarez-Sabín J, Montaner J.
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| Neurology 75(22):2033-5. No abstract available.
2010
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| 27 | APOE, ARMD1, ARMD2, ARMD3, ARMD7, ARMD8, ARMDA, ARMDC, ARMS2, C2, C3, CFB, CFH, HTRA1
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| Multilocus analysis of age-related macular degeneration.
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| Bergeron-Sawitzke J, Gold B, Olsh A, Schlotterbeck S, Lemon K, Visvanathan K, Allikmets R, Dean M.
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| Eur J Hum Genet ur J Hum Genet. 2009 Mar 4. [Epub ahead of print] 2009
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| 28 | AIFM1, HDAC2, HTRA1, LGALS9, MX1, NR4A2, PRDX2, TFNA13, UNC5D
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| Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy.
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| Colak D, Kaya N, Al-Zahrani J, Al Bakheet A, Muiya P, Andres E, Quackenbush J, Dzimiri N.
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| Genomics 94(1):20-31. Epub 2009 Mar 28.
2009
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| 29 | HTRA1
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| Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population.
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| Goto A, Akahori M, Okamoto H, Minami M, Terauchi N, Haruhata Y, Obazawa M, Noda T, Honda M, Mizota A, Tanaka M, Hayashi T, Tanito M, Ogata N, Iwata T.
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| J Ocul Biol Dis Infor 2(4):164-175.PMID: 20157352 2009
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| 30 | HTRA1
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| Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases.
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| Marzioni D, Quaranta A, Lorenzi T, Morroni M, Crescimanno C, De Nictolis M, Toti P, Muzzonigro G, Baldi A, De Luca A, Castellucci M.
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| Histol Histopathol 24(10):1213-22.PMID: 19688690 2009
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| 31 | HTRA1
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| Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo.
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| Chamberland A, Wang E, Jones AR, Collins-Racie LA, LaVallie ER, Huang Y, Liu L, Morris EA, Flannery CR, Yang Z.
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| J Biol Chem 284(40):27352-9. Epub 2009 Aug 5.PMID: 19657146 2009
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| 32 | HMGN2, HTRA1, ODC1
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| Identification of dilated cardiomyopathy signature genes through gene expression and network data integration.
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| Camargo A, Azuaje F.
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| Genomics 92(6):404-13. Epub 2008 Jul 1. 2008
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| 33 | ARMD7, ARMDA, ARMDC, CFH, HTRA1
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| Age-related macular degeneration .
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| Coleman HR, Chan CC, Ferris FL 3rd, Chew EY.
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| Lancet 372(9652):1835-45. 2008
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| 34 | ARMD7, HTRA1
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| Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration.
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| Gibbs D, Yang Z, Constantine R, Ma X, Camp NJ, Yang X, Chen H, Jorgenson A, Hau V, Dewan A, Zeng J, Harmon J, Buehler J, Brand JM, Hoh J, Cameron DJ, Dixit M, Tong Z, Zhang K.
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| Vision Res 48(5):685-9. Epub 2008 Jan 22.PMID: 18207215 2008
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| 35 | HTRA1, HTRA2, HTRA3
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| Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer.
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| Narkiewicz J, Klasa-Mazurkiewicz D, Zurawa-Janicka D, Skorko-Glonek J, Emerich J, Lipinska B.
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| Clin Biochem 41(7-8):561-9. doi: 10.1016/j.clinbiochem.2008.01.004. Epub 2008 Jan 16.
2008
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| 36 | HTRA1
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| Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population.
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| Mori K, Horie-Inoue K, Kohda M, Kawasaki I, Gehlbach PL, Awata T, Yoneya S, Okazaki Y, Inoue S.
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| J Hum Genet 52(7):636-41. Epub 2007 Jun 14. 2007
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| 37 | ACE, ARMD1, ARMD2, ARMD3, ARMD7, ARMD8, ARMDA, ARMDC, ARMS2, CFH, CX3CR1, FBLN5, HTRA1, MMP9, SOD2, VEGFA
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| Progress in defining the molecular biology of age related macular degeneration.
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| Lotery A, Trump D.
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| Hum Genet 122(3-4):219-36. Epub 2007 Jul 21. No abstract available. 2007
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| 38 | HTRA1
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| HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration.
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| Yoshida T, DeWan A, Zhang H, Sakamoto R, Okamoto H, Minami M, Obazawa M, Mizota A, Tanaka M, Saito Y, Takagi I, Hoh J, Iwata T.
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| Mol Vis 13:545-8.
2007
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| 39 | ARMD7, HTRA1, PLEKHA1
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| PLEKHA1-LOC387715-HTRA1 polymorphisms and exudative age-related macular degeneration in the French population.
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| Leveziel N, Souied EH, Richard F, Barbu V, Zourdani A, Morineau G, Zerbib J, Coscas G, Soubrane G, Benlian P.
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| Mol Vis 13:2153-9.PMID: 18079691 2007
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| 40 | HTRA1
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| HTRA1 promoter polymorphism in wet age-related macular degeneration.
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| Dewan A, Liu M, Hartman S, Zhang SS, Liu DT, Zhao C, Tam PO, Chan WM, Lam DS, Snyder M, Barnstable C, Pang CP, Hoh J.
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| Science 314(5801):989-92. Epub 2006 Oct 19. 2006
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| 41 | HTRA1
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| A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.
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| Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K.
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| Science 314(5801):992-3. Epub 2006 Oct 19. 2006
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| 42 | HTRA1
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| Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.
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| Chien J, Aletti G, Baldi A, Catalano V, Muretto P, Keeney GL, Kalli KR, Staub J, Ehrmann M, Cliby WA, Lee YK, Bible KC, Hartmann LC, Kaufmann SH, Shridhar V.
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| J Clin Invest. 116(7):1994-2004 2006
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| 43 | HTRA1
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| The role of human HtrA1 in arthritic disease.
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| Grau S, Richards PJ, Kerr B, Hughes C, Caterson B, Williams AS, Junker U, Jones SA, Clausen T, Ehrmann M.
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| J Biol Chem. 281(10):6124-9. 2006
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| 44 | ARMD8, ARMDS4, ARMS2, HTRA1, PLEKHA1
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| Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk.
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| Rivera A, Fisher SA, Fritsche LG, Keilhauer CN, Lichtner P, Meitinger T, Weber BH.
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| Hum Mol Genet 14(21):3227-36. Epub 2005 Sep 20. 2005
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| 45 | HTRA1
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| Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease.
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| Ozturk A, Desai PP, Minster RL, Dekosky ST, Kamboh MI.
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| Neurobiol Aging 26(8):1161-5. Epub 2004 Dec 18. 2005
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| 46 | HTRA1
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| Implications of the serine protease HtrA1 in amyloid precursor protein processing.
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| Grau S, Baldi A, Bussani R, Tian X, Stefanescu R, Przybylski M, Richards P, Jones SA, Shridhar V, Clausen T, Ehrmann M.
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| Proc Natl Acad Sci U S A 102(17):6021-6. 2005
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| 47 | HTRA1
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| A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer.
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| Chien J, Staub J, Hu SI, Erickson-Johnson MR, Couch FJ, Smith DI, Crowl RM, Kaufmann SH, Shridhar V.
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| Oncogene 23(8):1636-44. 2004
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| 48 | HTRA1
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| Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.
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| Murwantoko, Yano M, Ueta Y, Murasaki A, Kanda H, Oka C, Kawaichi M.
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| Biochem J 381(Pt 3):895-904. 2004
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| 49 | HTRA1
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| HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins.
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| Oka C, Tsujimoto R, Kajikawa M, Koshiba-Takeuchi K, Ina J, Yano M, Tsuchiya A, Ueta Y, Soma A, Kanda H, Matsumoto M, Kawaichi M.
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| Development. 131(5):1041-53. 2004
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| 50 | HTRA3, HTRA1
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| Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2.
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| Nie GY, Hampton A, Li Y, Findlay JK, Salamonsen LA.
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| Biochem J 371(Pt 1):39-48. 2003
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| 51 | HTRA1
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| Distribution of the serine protease HtrA1 in normal human tissues.
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| De Luca A, De Falco M, Severino A, Campioni M, Santini D, Baldi F, Paggi MG, Baldi A.
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| J Histochem Cytochem 51(10):1279-84. 2003
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| 52 | HTRA1
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| The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells.
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| Baldi A, De Luca A, Morini M, Battista T, Felsani A, Baldi F, Catricala C, Amantea A, Noonan DM, Albini A, Natali PG, Lombardi D, Paggi MG.
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| Oncogene 21(43):6684-8. 2002
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| 53 | HTRA1, HTRA2, HTRA3, HTRA4
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| The HtrA family of proteases: implications for protein composition and cell fate.
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| Clausen T, Southan C, Ehrmann M.
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| Mol Cell 10(3):443-55. Review. 2002
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| 54 | HTRA1
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| Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage.
|
| Hu SI, Carozza M, Klein M, Nantermet P, Luk D, Crowl RM.
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| J Biol Chem 273(51):34406-12. 1998
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| 55 | HTRA1
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| Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2.
|
| Zumbrunn J, Trueb B.
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| Genomics 45(2):461-2. 1997
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| 56 | HTRA1
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| Primary structure of a putative serine protease specific for IGF-binding proteins.
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| Zumbrunn J, et al.
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| FEBS Lett 398 : 187-192. 1996
|