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FLASH GENE

Symbol

SLC29A2

contributors: mct/npt - updated : 17-04-2010

HGNC name	solute carrier family 29 (nucleoside transporters), member 2
HGNC id	11004

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	9.30 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001532 12 - 2529 NP_001523 50 456 - Owen (2006)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine     highly endocrine brain diencephalon pituitary     Lymphoid/Immune thymus       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)   highly Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Slc29a2

intraspecies

homolog to SLC29A1

Homologene

FAMILY

SLC29A transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	bidirectional transporter that is involved in the disposition of naturally occurring nucleosides as well as a variety of anticancer and antiviral nucleoside analogs
	nucleobase transporter
	crucial to maintain physiological plasma levels of adenosine, thus modulating its several biological effects through adenosine receptor activation (Escudero 2008)
	prominent nucleoside transporters which are responsible for antitumor nucleoside uptake (Endo 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	nucleoside transporter

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

repressed by

HIF1A (HIF-1alpha-dependent repression increases mucosal adenosine signaling and attenuates hypoxia-associated inflammation of the intestine) (Morote-Garcia 2009)

Other

growth factor responsive

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in tumor cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS