Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CDC42

contributors: mct - updated : 19-06-2020

HGNC name	cell division cycle 42 (GTP binding protein, 25kDa)
HGNC id	1736

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MTCMR

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancers

Susceptibility

to osteoporosis

Variant & Polymorphism SNP	increasing the risk of osteoporosis

Candidate gene	for holoprosencephaly
Marker
Therapy target
	System Type Disorder Pubmed cancer     ZCL278 is a small molecule that specifically targets CDC42–ITSN1 interaction and inhibits CDC42-mediated cellular processes, thus providing a tool for research of CDC42 subclass of Rho GTPases in pathogenesis, such as cancer and neurological disorders miscelleaneous urinary chronic kidney disease maintaining necessary CDC42 would be one potent way to prevent proteinuria kidney diseases

ANIMAL & CELL MODELS

	mice with a keratinocyte-restricted deletion of the Cdc42 gene were born without obvious defects, but showed highly impaired hair coat development
	conditionally deletion of Cdc42 gene in telencephalic neural progenitors from mouse embryos abolishes the apical localization of PAR6, aPKC, E-cadherin, beta-catenin, and Numb proteins in the neuroepithelium, and severely impairs the extension of nestin-positive radial fibers
	brain and neuronal development are severely disrupted in Cdc42-deficient mice
	mice with podocyte-specific deletion of Cdc42 had severe proteinuria, podocyte foot process effacement, and glomerulosclerosis beginning as early as 10 days of age
	mice lacking Cdc42 specifically in kidney tubular epithelial cells died of renal failure within weeks of birth
	deletion of Cdc42 in mice could lead to increased adipocyte differentiation and decreased bone formation