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FLASH GENE
Symbol SH3GL3 contributors: mct - updated : 01-06-2022
HGNC name SH3-domain GRB2-like 3
HGNC id 10832
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH3 domain
  • one BAR domain
    • HOMOLOGY
    interspecies ortholog to murine Sh3d2c2
    homolog to rattus Sh3d2c1
    homolog to Drosophila endoA
    homolog to C.elegans T04D1.3
    intraspecies homolog to Src-homology 3 domain GRB2-like gene 3
    paralog to SH3GL1
    Homologene
    FAMILY endophilin family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • playing a regulatory role in synaptic vesicle recycling
  • promoting formation of insoluble polyglutamine-containing aggregates
  • promotes growth and migration of colon cancers, by linking membrane dynamics to GTPase regulation
  • acts as a potent tumor suppressor in lung cancer progression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text central nervous system development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to synaptojanin,dynamin 1 and HDEX1P (huntingtin exon 1 protein)
  • SH3GL2, SH3GL1, and SH3GL3, are recruited to the necks of endocytic clathrin-coated pits by its curvature sensitive BAR domain and binds both dynamin and synaptojanin
  • SH3GL3 stimulates cell migration by binding the Rac GEF TIAM1 leading to activation of small GTPase
  • SH3GL3 associates with ALCAM-containing early endocytic carriers and physically interacts with the cargo
  • acts as a novel tumor suppressor in glioblastoma tumorigenesis by inhibiting STAT3 signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • have a potential to serve as diagnostic and prognostic biomarker of lung cancer
    • Therapy target
    ANIMAL & CELL MODELS