Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SH3GL3 contributors: - updated : 17-10-2005
HGNC name SH3-domain GRB2-like 3
HGNC id 10832
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbraindiencephalonhypothalamus highly
 brainlimbic systemhippocampusdentate gyrus 
Reproductivemale systemtestis   
 male systemprostate  moderately
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell
Nervouspyramidal cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, lens, retina foveal, macular, eye, anterior segment ,RPE, choroid
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH3 domain
  • one BAR domain
  • HOMOLOGY
    interspecies ortholog to murine Sh3d2c2
    homolog to rattus Sh3d2c1
    homolog to Drosophila endoA
    homolog to C.elegans T04D1.3
    intraspecies homolog to Src-homology 3 domain GRB2-like gene 3
    paralog to SH3GL1
    Homologene
    FAMILY endophilin family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a regulatory role in synaptic vesicle recycling
  • promoting formation of insoluble polyglutamine-containing aggregates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text central nervous system development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to synaptojanin,dynamin 1 and HDEX1P (huntingtin exon 1 protein)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS