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FLASH GENE
Symbol SH3GL3 contributors: - updated : 17-10-2005
HGNC name SH3-domain GRB2-like 3
HGNC id 10832
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH3 domain
  • one BAR domain
  • HOMOLOGY
    interspecies ortholog to murine Sh3d2c2
    homolog to rattus Sh3d2c1
    homolog to Drosophila endoA
    homolog to C.elegans T04D1.3
    intraspecies homolog to Src-homology 3 domain GRB2-like gene 3
    paralog to SH3GL1
    Homologene
    FAMILY endophilin family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a regulatory role in synaptic vesicle recycling
  • promoting formation of insoluble polyglutamine-containing aggregates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text central nervous system development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to synaptojanin,dynamin 1 and HDEX1P (huntingtin exon 1 protein)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS